World’s Oldest DNA Recovered, And It Comes From A 1.2 Million-Year-Old Mammoth

An artist's impression of the steppe mammoths that preceded the woolly mammoth. Image credit: Beth Zaiken/Centre for Palaeogenetics

Ancient DNA has been recovered from a 1.2 million-year-old mammoth  the oldest DNA that’s ever been recovered by a long way. Not only is this incredible feat pushing the boundaries of what scientific methods are capable of, but the project has also revealed a new lineage in the mammoth family. The international study led by the Centre for Palaeogenetics in Stockholm was published today in the journal Nature.

The genetic material was acquired from the teeth of three mammoths found buried in the Siberian permafrost during the 1970s. Two of these specimens are over 1 million years old and predate the existence of the woolly mammoth, while the third is roughly 700,000 years old and represents one of the earliest known woolly mammoths. 

“This is by a wide margin  the oldest DNA ever recovered,” Professor Love Dalén, study author from the Centre for Palaeogenetics in Stockholm, said at a press conference on Tuesday. 

The second oldest of the specimens is from an ancient steppe mammoth (Mammuthus trogontherii), a direct ancestor of the wooly mammoth (Mammuthus primigenius), but the oldest specimen belongs to a previously unknown genetic lineage of mammoth, now referred to as the Krestovka mammoth. It also now looks like the iconic Columbian mammoth (Mammuthus columbi) that inhabited North America during the last Ice Age was a hybrid between this Krestovka lineage and the woolly mammoth.

The researchers conservatively estimate the oldest mammoth to be 1.2 million years old since this is the age of the geological section it was discovered in. However, mitochondrial genome data indicates the specimen could actually be up to 1.65 million years old, while the second mammoth could be 1.34 million years old. Whatever estimate you take, this is significantly older than the previous record-holder for the oldest sequenced DNA, which comes from a horse found preserved in Canadian permafrost dating to 780,000-560,000 years ago.

Mammoth tusk.
Woolly mammoth tusk emerging from permafrost on central Wrangel Island, located in northeastern Siberia. Image credit: Love Dalén.

The genome of these ancient mammals has seen much better days and has become extremely degraded over the millennia. Instead of a nice long strip of flawless genetic material, the researchers were confronted with billions of tiny odd fragments of DNA, which they had to painstakingly piece together. 

“A good analogy is to think about a puzzle. We have many, many small puzzle pieces and we’re trying to reconstruct the puzzle. The small piece you have, the harder it is to reconstruct the whole puzzle,” explained Dr Tom van der Valk, lead study author from the Centre for Palaeogenetics in Stockholm.

To make matters even harder, many of the puzzle pieces they come across are not even the mammoths but belong to bacteria or fungi that have contaminated the sample. Fortunately, they do have a few clues that help them piece together the puzzle. Just like looking on the front cover of the puzzle box for clues, the researchers have high-quality genomes of woolly mammoths and present-day elephant relatives to use for reference. 

Wait for it.

Now this research has shown what’s acheivable, the team believes it's theoretically possible to recover DNA that’s even older than the mammoths'. Professor Dalén noted that the Northern Hemisphere doesn’t contain any permafrost that’s older than 2.5 million years, so recovering DNA beyond this time may prove extremely difficult, if not impossible. Nevertheless, a wealth of natural history can be dug out from this widespread timeframe, not least some of the defining chapters in our own human story. 

"It's quite possible that, in the future, the methods will be there to recover DNA from human non-permafrost specimens that are close to 1 million years old," speculated Professor Dalén.

"The other alternative would be to find a Homo Erectus in the permafrost. No such finds have been done to date, but it's quite possible that someone will find human remains in the permafrost of this age. In that case, it would be more-or-less equally easy to get genomic DNA from these [hominin specimens] as it was for us to get DNA from the mammoths."

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