healthHealth and Medicine

Ancestors' Genetic "Memories" Could Be Passed On For 14 Generations


Robin Andrews

Science & Policy Writer



In Assassin’s Creed, the video game series-turned-movie, the protagonist is able to “remember” the memories of his long-dead ancestors through a special machine named the Animus. Although this is not actually possible, sadly, the idea that we “experience” what our ancestors went through isn’t actually wrong.

In fact, based on a startling new study, it appears that the experiences of your ancestor that lived 14 generations ago are potentially having an effect on your life right now.


Writing in the journal Science, a team led by Barcelona's Centre for Genomic Regulation and the Josep Carreras Leukaemia Research Institute say that their discovery, which was based on a study of nematode worms, is the most long-term form of the phenomenon ever discovered in a living animal.

content-1492784073-1-environmenta.jpgAlthough it’s not yet observed in humans, the differences in the genetic makeup of humans and worms aren’t too large. We know that the lives of our grandparents do indeed have influences on our own day-to-day behaviors, but there’s now a chance that an ancestor born centuries ago may still be playing a hand in your life - assuming, of course, what applies to nematode worms applies to humans, and that's a big if.

First, let’s step back a bit and take a look at the basic science behind this highly peculiar characteristic of biology.

Your genes are inherited from your parents, and theirs from their parents before them. If these mutate, your genetic inheritance changes with it. However, changes to how your genome “expresses” itself – how it behaves, essentially – can also occur due to environmental changes, like ingested chemicals, exercise, and psychological issues.


When your ancestor goes through a period of excessive stress, this “experience” can be added to your genome. An extra layer of information is placed on top of your DNA sequences. The DNA sequence itself doesn’t change, but its “clothes” do, so to speak. Generally speaking, this is known as the vaguely defined field of epigenetics, which means “outside genetics”.

The authors of a new Science paper describe it more precisely as “transgenerational transmission of environmental information.” It has already been seen in humans – Holocaust survivors’ descendants, for example, have lower levels of the stress-hormone cortisol in their blood, which means they’re more vulnerable to stress and fear.

Image in text: C. elegans worm. Adam Klosin/CRG

This particular study looked at C. elegans nematodes, types of roundworms with very short lifespans. The researchers genetically engineered them to carry a glowing gene, a protein that fluoresced, so they could track it under UV light.


They then placed the worms in a cold environment and watched as the gene glowed, but dimly. Moving them to a warm environment, they saw the gene glow far more brightly. When they were moved back to the cold room, the gene continued to glow, which suggested the “memory” of the warm environment was maintained.

Incredibly, when these worms reproduced, this memory, via this glowing gene, was passed on through an unprecedented 14 generations, no matter whether they received it via eggs or sperm. This means that their offspring would be “aware” of the warm environment even without having experienced it themselves.

"We don't know exactly why this happens, but it might be a form of biological forward-planning,” lead author, Adam Klosin of the European Molecular Biology Organization, said in a statement.

“Worms are very short-lived, so perhaps they are transmitting memories of past conditions to help their descendants predict what their environment might be like in the future,” co-author Tanya Vavouri, a researcher from the Josep Carreras Leukaemia Research Institute in Spain, added.


The Assassin's Creed series uses the concept of "genetic memory," which isn't too dissimilar from what is described in this paper. 20th Century Fox via YouTube

So if worms can “remember” the experiences of their long-gone ancestors, can humans? For now, that question will have to remain tantalizingly unanswered – but it’s definitely not outside the realm of possibility.


healthHealth and Medicine
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  • epigenetics,

  • memories,

  • environmental,

  • inheritance,

  • experiences,

  • assassin's creed,

  • 14 generations