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The Composition Of Your Gut Microbiome May Give Away Your Age, Says New Study

Bacteria Bacteroides fragilis - just one of the hundreds of species of bacteria found in the colon. Kateryna Kon/shutterstock

Programmers have developed an artificially intelligent algorithm, which they say can predict how old someone is with remarkable precision. All it needs is a sample of an individual's gut microbiome and it can narrow down their age to within four years, says a study available on the pre-print server bioRxiv, which is currently awaiting peer-review. 

Your gut microbiome is a unique ecosystem consisting of trillions of microorganisms – some good, some bad, and some somewhere in-between. And we are only just starting to grasp how important it is to our health, our behavior, even how we process emotions like fear. In the past year alone, studies have been published linking gut flora to autoimmune diseases, degenerative disorders like Parkinson's, and autism. Another study examined the ways various gut microbiota may manipulate our moods via their waste products. 


The latest study suggests there are consistent – and, therefore, predictable – ways the gut microbiome changes over a lifetime that make it possible for machine-learning software to accurately guess our age to within four years needing only a sample of our gut microbiome. 

The algorithm used was designed by an artificial intelligence company called InSilico Medicine. Programmers used over 3,663 gut bacteria samples from 1,165 healthy individuals aged between 20 and 90 and from Austria, China, Denmark, France, Germany, Kazakhstan, Spain, Sweden, and the USA to train and then test their algorithm. Ninety percent of the samples were used in the training stage. The remaining 10 percent were used to test the algorithm's accuracy. 

The result? Discounting a few anomalies, it could pinpoint the host's age to within 3.94 years, beating a previous model, which could predict a person's age with only 10 to 15 percent more accuracy that chance. 

But that's not all. The machine was also able to work out which bacteria species were most important when determining a person's age. Apparently, out of hundreds of possible contenders, there are 39 species of gut flora that convey the most significant information when it comes to telling how old a person is.


The good news is that it isn't all downhill when you hit 30 – in fact, the researchers found no significant increase in the ratio of harmful to beneficial bacteria as we age. Instead, the increase of bacteria that may promote the detrimental effects of aging is balanced out by a decrease in harmful bacteria, related to an increase in "memories" that help us fight off pathogens we have already been exposed to. 

The study authors are careful to point out that any differences in gut microbiota between the elderly and the young cannot simply be put down to the process of aging. Diets and lifestyle have changed significantly over the last 100 years and so differences may be more reflective of that rather than anything else.

"In other words, any features identified today as associated with the youth may become the signature of the elderly in 50 years, provided global diet and lifestyle keeps changing," the study authors explain.

"Depending on the extent of such microbiological 'generation gap,' any future intestinal aging clock may need to be regularly updated to account for an ever-changing environmental context."


Again, this study has yet to be peer-reviewed so we'll have to wait to see if these results are confirmed.


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