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Health and Medicine

Clinical Trial Of Alzheimer's Vaccine Recruits First Patient

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Jack Dunhill

Social Media Coordinator and Staff Writer

clockNov 12 2021, 16:10 UTC
alzheimer's

The Phase 1b trial will judge the safety of the vaccine. Image Credit: Ocskay Mark/Shutterstock.com

An early Phase 1b clinical trial for an Alzheimer’s disease vaccine has recruited its first patient, states vaccine developer Alzinova AB. The vaccine, called ALZ-101, contains antibodies that directly target neurotoxic build-ups of protein, amyloid-beta oligomers, that develop in Alzheimer’s patients and are thought to block important brain signaling. 

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These aggregations are found up to 20 years before developing the disease, and the hope is a vaccine that prevents them from forming in the brain may prevent the cognitive deficits and memory loss that arises with Alzheimer’s. 

"It is very satisfying that ALZ-101 has now entered clinical testing in an area with such a huge unmet medical need. We are looking forward to continuing the development of this potential disease-modifying treatment with the long-term goal to treat and prevent the onset and progression of this devastating disease," says Kristina Torfgård, CEO of Alzinova AB, in a statement.  

The trial will be double-blind, placebo-controlled, and randomized, the gold standard for an early Phase 1 trial such as this. Phase 1 trials are conducted to evaluate the safety and dosage of the experimental drug or vaccine, but this trial will also look to assess the immune response elicited by the vaccine. 

[h/t: Alzheimer's News Today]


Health and Medicine
  • vaccines,

  • The Brain,

  • Alzheimer's

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