Spider Venom Could Help Save Brains After Strokes

 

You may not like the look of your savior, but this species of spider has a molecule in its venom that protects against the damage after strokes. Bastian Rast

Stroke victims may one day experience far less brain damage, but arachnophobes might not want to think too closely about their salvation. A molecule found in the venom of Australian funnel-web spiders has been shown to be highly effective at preventing stroke damage in rats, and human trials are next.

Strokes kill an estimated 6.4 million people a year. Far more are left with damage to parts of their brain that can range from mild to utterly debilitating, with treatment making up approximately 3 percent of global healthcare costs. At least 85 percent of these are ischemic strokes, where interruption to blood flow causes the loss of oxygen to part or all of the brain, inducing the death of brain cells.

The curious thing, Professor Glenn King of the University of Queensland told IFLScience, is that, damaging as oxygen deprivation can be, most of these deaths are unnecessary. They result from a process where the brain responds to oxygen loss by triggering cell death through the Acid-sensing ion channel (ASIC1a). Yet if ASIC1a serves any useful purpose, it is not clear what it is. When ASIC1a is turned off in rats they appear unharmed, and can survive ischemic strokes with far less damage than their unmodified counterparts.

We don't yet know the same is true in humans, but it appears likely, and naturally the race is on to find a drug that can block ASIC1a, and be administered quickly to stroke patients. Early this century it was discovered that the PcTx1 molecule in the venom of North American tarantulas has just such a blocking effect

King was studying this molecule while one of his students, Sandy Pineda, was investigating the venom of Fraser Island funnel-web spiders. King told IFLScience that Pineda came to him one day saying: “You know that tarantula molecule you're working on, I've found one that looks just like it.” This was surprising, since funnel-webs and tarantulas are not closely related. King told Pineda to keep investigating, and she eventually found that the funnel-web molecule closely resembles two PcTx1 molecules with a small bridge between.

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