A Hidden Code In Our DNA Explains How New Pieces Of Genes Are Made

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Danielle Andrew 10/01/2017, 19:17

The ConversationWe’re all here because of mutations. Random changes in genes are what creates variety in a species, and this is what allows it to adapt to new environments and eventually evolve into completely new species. But most random mutations actually disrupt the functions of our genes and so are a common source of genetic diseases.

This ambiguity creates a great challenge. On the one hand, mutations are needed for biological innovation, and on the other hand they cause diseases. How does nature resolve this conflict? Recent research by me and my colleagues suggests that one answer could lie in a genetic code that allows evolution to innovate while minimising the disruption this can create.

This code is hidden within a part of our genome (the complete set of our genetic material) known as repetitive genetic elements, which we now know plays a key role in evolution. These elements are sequences within our DNA that can make many copies of themselves. In order to build the proteins that our bodies need, our cells take instructions from our DNA by transcribing it into a similar molecule called RNA. But in rare cases, instead of building a protein, some RNA molecules convert back into DNA and insert themselves at new locations in our genome.

In this way, the repetitive elements can continually create new copies of themselves. As a result, the human genome contains thousands of repetitive elements that are not present in any other species because they have copied themselves since humans evolved.

But repetitive elements aren’t just useless copies. Barbara McClintock, the scientist who discovered them in 1948, showed they can act as switches that switch genes on and off in maize. This was initially thought to be an obscure phenomenon with no relevance for humans. Yet now it has become clear that repetitive elements are an important toolkit for evolution. By turning genes on and off, the repetitive elements can influence what characteristics a species evolves. They have been useful for biological innovations, such as evolution of pregnancy in mammals.

Perhaps the most elegant example of this is in the evolution of the peppered moth. This moth normally has light-coloured wings, but during Britain’s industrial revolution a repetitive element inserted itself into the gene that controls the colour pattern of the wings. As a result, a black strain of the peppered moth evolved and this allowed it to blend in and escape its predators amid the polluted environment.

Industrial camouflage. Shutterstock

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